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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors
Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 383-388 doi: 10.1007/s11684-016-0488-1
The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming theacquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitorresistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor
Keywords: EGFR tyrosine kinase inhibitor AZD9291 EAI045
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
Frontiers of Medicine 2020, Volume 14, Issue 3, Pages 273-283 doi: 10.1007/s11684-019-0728-2
Keywords: hepatocellular carcinoma tyrosine kinase inhibitor check point inhibitor anti-angiogenesis
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 427-437 doi: 10.1007/s11684-018-0672-6
Keywords: targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor
Peter B. Alexander,Xiao-Fan Wang
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 134-138 doi: 10.1007/s11684-015-0396-9
Keywords: targeted therapy drug resistance receptor tyrosine kinases cancer
LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 235-238 doi: 10.1007/s11684-008-0044-8
Keywords: hyperphosphorylation PP2A activity cellular regulation siRNA siRNA transfection
Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells
Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 341-346 doi: 10.1007/s11684-009-0067-9
Keywords: human cervical cancer cells apoptosis phosphatidylinositol 3-kinase (PI3K)/Akt FLICE-like inhibitory
Precision medicine in acute lymphoblastic leukemia
Ching-Hon Pui
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 689-700 doi: 10.1007/s11684-020-0759-8
Keywords: acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy
Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang
Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 344-353 doi: 10.1007/s11684-018-0639-7
Keywords: chronic myeloid leukemia (CML) dasatinib tyrosine kinase inhibitor long-term follow-up
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 46-53 doi: 10.1007/s11684-010-0010-0
Keywords: mitogen-activated protein kinase drug target inhibitor signal transduction disease
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y
Keywords: pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinaseinhibitor
Dual faces of SH2-containing protein-tyrosine phosphatase
Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 275-279 doi: 10.1007/s11684-012-0216-4
PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses toAgainst original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first
Keywords: PTPN11/Shp2 leukemia hepatocellular carcinoma mutation
Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 462-476 doi: 10.1007/s11684-013-0270-6
Keywords: drug resistance cancer stem cell checkpoint kinase 1 (CHK1) PF-00477736 lung cancer tumorigenicity
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
Yuan CHEN, Qi TIAN
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 70-76 doi: 10.1007/s11684-011-0119-9
Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.
Keywords: protein kinase C ? signal transduction neurogenic disease
Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 102-110 doi: 10.1007/s11684-021-0850-9
Keywords: COVID-19 RAS inhibitor hypertension all-cause mortality
CHEN Guowei, XI Pengge, XU Deqian, YU Hanqing
Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1, Pages 63-66 doi: 10.1007/s11783-007-0012-6
Keywords: uncoupling coefficient Cu minimization presence uncoupling
Title Author Date Type Operation
Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors
Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu
Journal Article
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
Journal Article
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
Journal Article
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
Peter B. Alexander,Xiao-Fan Wang
Journal Article
Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation
LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing
Journal Article
Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells
Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,
Journal Article
Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving dasatinib: efficacy and safety
Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang
Journal Article
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
Journal Article
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker and implicates potential therapeutic targets
Journal Article
Dual faces of SH2-containing protein-tyrosine phosphatase
Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng
Journal Article
Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like
Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale
Journal Article
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
Yuan CHEN, Qi TIAN
Journal Article
Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID
Journal Article